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F. D. JOHNSTONE, R. CULLEN and G. YOUNGSON

Summary.

The theory that oestriol and oestradiol have specific patterns of effect on the lower and upper reproductive tracts was investigated in the spayed rat. At dose levels which produced similar increases in uterine wet weight, there was no difference in decrease in tensile strength of the cervix. From a review of the literature, it is suggested that oestriol may exert a pronounced effect on the cervix in late pregnancy, but not because of any specific `polar' effect.

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G. J. R. HOVELL, R. CULLEN and K. BROWN-GRANT

The infusion of solutions of iodine into the uterus through the cervical canal has been practised as a therapeutic measure in certain cases of infertility in farm animals. Little is known about the possible mode of action of such treatment, though Ekman, Holmberg, Settergren & Thorell (1965) have shown that iodide is rapidly absorbed from the uterine lumen in the cow and have suggested that systemic as well as local effects might be involved. On the other hand, iodide has been shown to be present in the cervical mucus in women at a concentration above that in plasma (see Brown-Grant, 1961, for references) and in the rat, a very high concentration of iodide relative to plasma has been demonstrated in the oviduct and