Search Results
You are looking at 1 - 1 of 1 items for
- Author: Rujun Ma x
- Refine by access: All content x
Search for other papers by Chuwei Li in
Google Scholar
PubMed
Search for other papers by Zhang Qian in
Google Scholar
PubMed
Search for other papers by Hong Zhang in
Google Scholar
PubMed
Search for other papers by Xie Ge in
Google Scholar
PubMed
Search for other papers by Li Chen in
Google Scholar
PubMed
Search for other papers by Ting Tang in
Google Scholar
PubMed
Search for other papers by Mengqi Xue in
Google Scholar
PubMed
Search for other papers by Zhaowanyue He in
Google Scholar
PubMed
Search for other papers by Lu Zheng in
Google Scholar
PubMed
Search for other papers by Chun Cao in
Google Scholar
PubMed
Search for other papers by Kemei Zhang in
Google Scholar
PubMed
Search for other papers by Rujun Ma in
Google Scholar
PubMed
Search for other papers by Bing Yao in
Google Scholar
PubMed
With an increase in the mean age at parturition worldwide, female reproductive aging has become a key health problem. Advanced maternal age is reflected by decreased oocyte quality; however, the molecular mechanisms of oocyte aging are uncharacterized. O-linked N-acetylglucosamine (O-GlcNAc), a dynamic posttranslational modification, plays a critical role in the development of many age-related diseases, yet it remains unclear whether and how O-GlcNAc participates in oocyte aging. Here, we found that global O-GlcNAc was elevated in normal biological aging mice oocytes (32-34 weeks) which were characterized by meiotic maturation failure and impaired mitochondrial function. Specifically, O-GlcNAc targeted the mitochondrial fission protein dynamic-related protein 1 (DRP1) to meditate mitochondrial distribution in the process of aging. Using the O-GlcNAcase (OGA) pharmacological inhibitor Thiamet-G and OGA knockdown (OGA-KD) to mimic the age-related high O-GlcNAc in young oocytes from 6-8 week-old mice mimicked the phenotype of oocyte aging. Moreover, reducing O-GlcNAc levels in aging oocytes restored spindle organization to improve oocyte quality. Our results demonstrate that O-GlcNAc is a key regulator of meiotic maturation that participates in the progression of oocyte aging.