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M. M. Misro, Harpreet Kaur, Sudha Mahajan and S. K. Guha

Summary. An implantable miniature biogalvanic cell was developed to kill the spermatozoa in the vas deferens by an electric current. Experiments in vitro and in vivo showed that a combination of aluminium/silver electrodes connected with platinum wires with the vas deferens fluid as an electrolyte is effective in killing spermatozoa. Female rats paired with males having biogalvanic devices in the vas deferens, which remained patent, did not produce any young.

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The effect of oxytocin administration on the oestrous cycle was studied in sixteen uterine-intact and thirty-two surgically prepared unicornual heifers. Unilateral hysterectomy was performed on Day 3 of the oestrous cycle and oxytocin or an equivalent volume of physiological saline was administered daily from Day 3 to Day 7 or 8. Oxytocin produced significantly shorter oestrous cycles in the intact heifers and in the unicornual heifers with the retained uterine horn adjacent to the cl, but not in the unicornual heifers with the retained horn opposite to the cl. These results strongly suggest that at least part of the effect of oxytocin is exerted through local, utero-ovarian channels. A unilateral effect of the uterus on the cl was demonstrated in unicornual heifers that did not receive oxytocin. The oestrous cycles were extended and the cl persisted when the retained horn was opposite to the cl, but not when the retained horn was adjacent to the cl.

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Kusum Vermat, M. M. Misro, H. Singh, Sudha Mahajan, A. R. Ray and S. K. Guha

Summary. An alternate co-polymer of styrene and maleic anhydride was dissolved in dimethylsulphoxide and injected into the vas deferens of rats. The polymer was retained in the vas deferens and the morphological changes detected were confined to the mucosa. When the polymer was removed by flushing dimethylsulphoxide, the mucosal structure became normal within 2 weeks.