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  • Author: S. R. Chowdhury x
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AJIT GOSWAMI, AMIYA B. KAR and S. R. CHOWDHURY

Summary.

Uterine lipid components of mice were analysed during different stages of the oestrous cycle and after ovariectomy and replacement therapy. During oestrus, and in ovariectomized animals subjected to oestrogen treatment, there was a fall in total lipid concentration and percentage of triglycerides, but an increase in concentration of phospholipids, as compared to the corresponding di-oestrous values. Progesterone antagonized the effect of oestrogen and restored the triglyceride concentration to the di-oestrous level. In comparison, the effect of progesterone on total lipids or phospholipids was less marked. There was no significant change in uterine cholesterol concentration during different stages of the oestrous cycle or after ovariectomy and hormone therapy. In general, the fatty acid components of the lipid constituents showed lower iodine values and increased saturation under the influence of oestrogen. These changes were more evident in triglyceride and phospholipid fractions than in the cholesterol ester fraction. Of the nitrogenous bases of phosphoglycerides, serine showed a more marked increase than the other components. The possible significance of these findings is discussed.

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AMIYA B. KAR, V. P. KAMBOJ, AJOT GOSWAMI and S. R. CHOWDHURY

Summary.

An intra-uterine suture did not evoke any acute changes in the rat uterus. However, prolonged presence of the suture provoked keratinized metaplasia of the epithelium in 20% of the animals and cystic glandular hyperplasia in 10%. The O2 uptake rate was doubled in the treated horn but other biochemical constituents did not undergo any noteworthy change. Pregnancy was invariably prevented in the treated horn. However, this effect was reversed by removal of the suture provided there were no gross abnormalities in the uterus. Animals fitted with the suture before puberty also conceived only in the control horn when their fertility was tested during adult life. The removal of the suture led to pregnancy in both horns. This indicated that the reproductive potential of these animals was not disturbed due to the insertion of the suture during prepuberal life.

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G. Singh, M. M. Singh, S. C. Maitra, W. Elger, V. Kalra, S. N. Upadhyay, S. R. Chowdhury and V. P. Kamboj

Summary. RU-38486 or ZK-98734 treatment (3 mg/day, s.c.) to intact or hysterectomized adult female rats on Days 5–7 post coitum induced changes characteristic of luteolysis. Ultrastructurally, the luteal cells exhibited an extensive vacuolization of the cytoplasm and perinuclear areas, degeneration of mitochondrial cristae, massive accumulation of lipid droplets, increase in number of lysosome like granules and heterochromatinization of the nucleus. In general, RU-38486 induced more marked degeneration of the luteal cells than did ZK-98734. There was also a significant decrease in peripheral plasma progesterone concentrations in treated rats. We suggest that these antiprogestagens act via inhibition of luteal function in addition to their antagonism at the uterine progesterone receptor level.

Keywords: antiprogestagens; ultrastructure; corpora lutea; progesterone; rat