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SHEILA F. STEWART, D. GAWLAK and SUSAN KOPIA

Hemicastration in the rat is followed by hypertrophy of the remaining gonad (Heller, Heller & Sevringhaus, 1942), presumably as a result of increased pituitary secretion of gonadotrophins (Benson, Sorrentino & Evens, 1969). Howland (1972) recently demonstrated that caloric restriction interfered with ovarian hypertrophy and speculated that this was due to a decreased level of hypothalamic releasing factors. The present study was undertaken to determine if caloric restriction affected gonadal hypertrophy in the male as in the female.

Immature Sprague-Dawley male rats, weighing 35 to 40 g, were used since the mature male does not respond with gonadal hypertrophy when hemicastrated (Means & Hall, 1967). For comparison with the results obtained by Howland (1972), adult female rats weighing 160 to 180 g were used, but for comparison with the males, an immature female was used. Both sexes were

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SHEILA F. STEWART, SUSAN KOPIA and D. L. GAWLAK

Warner-Lambert Research Institute, Morris Plains, New Jersey 07950, U.S.A. (Received 13th February 1975)

Dietary regimens have been shown to influence the secretion of gonadotrophins (Mulinos & Pomerantz, 1940; Leathem, 1958; Srebnik & Nelson, 1963), the changes occurring as the result of decreased hypothalamic content of FSH-RF and LH-RF (Piacsek & Meites, 1967) or FSH-RF activity (Negro-Vilar et al., 1971). Root & Russ (1972) demonstrated that fasting reduced serum FSH levels in intact male rats whereas Howland (1971a) reported that no change occurred in fasted female rats. Root & Russ (1972) and Ibrahim & Howland (1972) found that castration increased serum FSH levels, but the release of FSH was inhibited in the females and increased in the males when they were also fasted. A similar increase in FSH secretion in both sexes has been shown many times (Benson et al., 1969; Ibrahim & Howland, 1972; Howland & Skinner, 1973; Stewart et