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  • Author: T. C. Anand Kumar x
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UPTAKE OF TRITIATED THYMIDINE BY PRIMORDIAL GERMINAL CELLS IN THE OVARIES OF THE ADULT SLENDER LORIS

G. F. X. DAVID, T. C. ANAND KUMAR, and T. G. BAKER

Summary.

Six adult lorises (Loris tardigradus lydekkerianus) in anoestrus were selected for study. Four of the animals were pretreated with an injection of 0·5 mg oestradiol-17β, two were given FSH (2 × 50 i.u. with a 12-hr interval), while the remaining two were not treated with hormones. All of the animals were subsequently given a subcutaneous injection of 0·5 mCi [3H]thymidine and their ovaries were recovered for autoradiography 24 hr later.

It was found that the non-follicular germinal cells within `nests' in the ovarian cortex actively incorporated the radioisotope. Some of the labelled germinal cells appeared to reach the pachytene-diplotene stages of meiotic prophase, although this would not be expected to occur in such a short time after treatment. None of the labelled germinal cells appeared to enter upon the phase of follicular growth, although a few (especially in ovaries treated with oestrogen and FSH) seemed to be in primordial follicles consisting of an incomplete layer of flattened cells.

DOI:
https://doi.org/10.1530/jrf.0.0410447
Volume 41: Issue 2,
Pages:
447–451 (5 total)
Free access

Reproductive exocrine and endocrine profile of female langur monkeys, Presbytis entellus

N. K. Lohiya, R. S. Sharma, C. P. Puri, G. F. X. David, and T. C. Anand Kumar

Summary. In 5 caged langurs menstrual cycle length (for 125 cycles) varied from 18 to 45 days with a mean ± s.d. of 26·3 ± 3·6 days. Menstruation lasted for 2 days. A distinct cycle of vaginal smear cells was observed with a maximum cornification on Day 10 coinciding with the serum oestradiol peak. A monophasic pattern of vaginal temperature with a significant nadir on Day 11, 1 day after the oestradiol peak, was observed. Serum sialic acid concentrations directly reflected the oestrogenic activity and showed a significant peak on Day 10, coinciding with the oestradiol peak and was followed by a progesterone rise. Langurs menstruated throughout the year without showing any sign of summer amenorrhoea. We suggest that maximum cornification, vaginal temperature nadir and serum sialic acid peak could be used as markers for prediction and detection of the time of ovulation in langur monkeys.

Keywords: langur; vaginal temperature; serum oestradiol; vaginal smear patterns; serum sialic acid; ovulation; menstrual cycle

DOI:
https://doi.org/10.1530/jrf.0.0820485
Volume 82: Issue 2,
Pages:
485–492 (8 total)
Free access

Reproductive endocrine effects of intranasal administration of norethisterone to adult female rhesus monkeys (Macaca mulatta)

V. Puri, G. F. X. David, A. K. Dubey, C. P. Puri, and T. C. Anand Kumar

Summary. Intranasal administration of norethisterone at a daily dose of 9 μg between Days 5 and 14 of the menstrual cycles blocked ovulation in 10 out of 17 adult female monkeys. Serum concentrations of hormones indicated that ovulation was blocked due to a suppression of the mid-cycle, oestradiol-induced LH surge. Ovarian follicular activity in the treated menstrual cycles was not affected by norethisterone but there was a marked delay in the onset of the mid-cycle oestradiol surge in most of the treated animals. The duration of the menstrual cycle length after the oestradiol peak was significantly reduced in all the treated monkeys, indicative of a shortened luteal phase.

DOI:
https://doi.org/10.1530/jrf.0.0760215
Volume 76: Issue 1,
Pages:
215–220 (6 total)