Division of Allied Health and Life Sciences, University of Texas, San Antonio, Texas 78285, U.S.A.
It has been suggested that sensitivity of the hypothalamic-pituitary unit to feedback inhibition by androgens may decline at the onset of puberty in the rat (Negro-Vilar, Ojeda & McCann, 1973), and that effects of gonadotrophins on testis weight may be greater before than after puberty (Swerdloff, Jacobs & Odell, 1972). In rats, the epithelium of the seminal vesicle is most sensitive to androgen stimulation between 40 and 60 days of age (Hooker, 1942), and the sensitivity of the seminal vesicles in neonatally castrated mice to androgens during adulthood is influenced by neonatal androgen treatment (Bronson & Desjardins, 1969; Bronson, Whitsett & Hamilton, 1972). The present studies were therefore undertaken to examine the effects of various androgen treatments between weaning and puberty on the growth of seminal vesicles of castrated mice.
The mice used were from