Search Results

You are looking at 1 - 1 of 1 items for

  • Author: V. Puri x
  • All content x
Clear All Modify Search
Free access

V. Puri, G. F. X. David, A. K. Dubey, C. P. Puri, and T. C. Anand Kumar

Summary. Intranasal administration of norethisterone at a daily dose of 9 μg between Days 5 and 14 of the menstrual cycles blocked ovulation in 10 out of 17 adult female monkeys. Serum concentrations of hormones indicated that ovulation was blocked due to a suppression of the mid-cycle, oestradiol-induced LH surge. Ovarian follicular activity in the treated menstrual cycles was not affected by norethisterone but there was a marked delay in the onset of the mid-cycle oestradiol surge in most of the treated animals. The duration of the menstrual cycle length after the oestradiol peak was significantly reduced in all the treated monkeys, indicative of a shortened luteal phase.