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W. JÖCHLE and E. SCHILLING

This paper records observations made on conception in sows treated with a long-acting androgen-oestrogen mixture. The observations were made as part of an experiment originally undertaken to examine the value of treatment with this agent for the diagnosis of pregnancy in pigs. It has previously been observed that administration of a similar mixture was followed by heat in cattle previously showing ovulation in the absence of heat. By the same treatment an ovulatory heat was induced in anoestrous, barren animals, but existing pregnancies were not disturbed (Jöchle, 1964). It seemed probable that the existence of pregnancy would be established if heat failed to occur following administration of the agent. Two milligrammes oestradiol valerate and 5 mg testosterone enanthate were administered to sows 9 to 12 days following service. The experimental group comprised ninety-eight German Landrace
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W. JÖCHLE, H. ESPARZA, T. GIMÉNEZ and M. A. HIDALGO

Summary.

Progesterone (100 mg) applied 3 days before and 5 days after a single administration of 10 mg flumethasone on Day 270 of pregnancy in sixteen cows and thirteen heifers, successfully prevented premature parturition which was otherwise promptly induced by the corticoid. At this dose level and timing, progesterone interfered significantly with the sequence of events preceding, accompanying and following parturition. As a result, preparation of presentation of the fetus for parturition was either delayed or prevented, dystocia was frequent, the percentage of stillborn calves was significantly elevated, calf viability was impaired and placental retention, which occurs in about 80% of corticoid-induced parturitions, was not influenced.