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A. SUNDBY, R. TOLLMAN and W. VELLE

Summary.

The spontaneous diurnal variation of peripheral plasma testosterone concentrations in four bulls was established and then the long-term effect of a single intravenous or intramuscular injection of HCG on testosterone levels was studied. Intravenous and intramuscular HCG injections produced, within ½ hr and 3 hr, respectively, a rapid rise of testosterone to levels equivalent to the highest values seen in the diurnal pattern. A second increase of up to × 2 to × 3 the highest values of the diurnal cycle was observed 2 days after the injection of HCG, and the testosterone level remained high for at least 3 to 4 days after plasma levels of HCG were no longer detectable. The pattern of diurnal variation after HCG revealed an attenuation of the extensive spontaneous variation and high levels with only slight fluctuations were maintained.

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P. FYLLING, Ø. V. SJAASTAD and W. VELLE

Premature parturition in sheep following administration of synthetic corticoids is now well documented (Van Rensburg, 1967; Bosc, 1970; Skinner, van Blom, Gouws & Jöchle, 1970; Fylling, 1971). In the cow, both premature parturition (Adams, 1969; Hansen & Christiansen, 1971; Karg, Böhm, Günzler & Müller, 1971; L. E. Edquist, personal communication) and mid-term abortion (L. E. Edquist, personal communication) have been reported following such treatment. Induction of abortion in sheep by synthetic corticoids has not been reported so far. This paper presents a study on the effect of dexamethasone given to ewes during mid-term pregnancy.

Five ewes of the Dala breed, all 80 days pregnant, were included in the investigation. The mean gestational period in this breed is 148 days. The animals received intramuscular injections of 2·5 mg dexamethasone four times

No.5 84 86 88 Days of