The authors performed therapeutic donor insemination in 219 women. In 114 cases, 132 conceptions were obtained. The average number of inseminations for one conception was 3·8. More than half of the women in the `unsuccessful' subgroup did not exhaust the therapeutic possibilities of this treatment, i.e. aid extending over the period of five to six cycles. Seventeen losses in pregnancy, or within 10 days after delivery, correspond to less than 13%. One boy out of 108 living children (fifty boys and fifty-eight girls) had a developmental anomaly (penile hypospadias).