, clinical investigations of relative telomere length and its associations with male and female fertility have become more prevalent ( Table 1 ). Going through the evolving literature, it is apparent that oxidative stress, one of the most common underlying
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Aron Moazamian, Parviz Gharagozloo, Robert J Aitken, and Joël R Drevet
Cristian O’Flaherty and Eleonora Scarlata
aerobic metabolism ( Fig. 1 ). ROS have a dual role in spermatozoa; at high concentrations, they promote oxidative stress, damaging lipids, proteins, and DNA of the cell ( Aitken et al. 2022 ), but at low and controlled amounts, they trigger the redox
Ewa Rudnicka, Anna Maria Duszewska, Marek Kucharski, Paweł Tyczyński, and Roman Smolarczyk
debated causes of PCOS is oxidative stress (OS) ( Murri et al. 2013 , Desai et al. 2014 ). However, it has not been established whether oxygen stress affects the development of PCOS or whether it is only a secondary disorder resulting from
R John Aitken, Elizabeth G Bromfield, and Zamira Gibb
of cell viability and functionality in the process. Thus, when the production of ROS becomes enhanced, and/or antioxidant defences become compromised, a state of oxidative stress arises generating pathological outcomes. These pathologies include
Tessa Lord and R John Aitken
control this process and considers the current means by which post-ovulatory ageing can be prevented or delayed. Specifically, in light of recent research, we revisit the proposal that oxidative stress may act as the ‘trigger’ for a cascade of other events
Hua-Yu Lian, Yan Gao, Guang-Zhong Jiao, Ming-Ju Sun, Xiu-Fen Wu, Tian-Yang Wang, Hong Li, and Jing-He Tan
balance is disrupted toward an overabundance of ROS, oxidative stress occurs ( Agarwal et al . 2005 ). Oxidative stress has been identified to play a key role in the pathogenesis of subfertility in both males and females. However, whereas the adverse
Fei Liu, Zhen-Zhen Chen, Jie Zhao, Yuan-Qiang Zhang, Jing Ma, and Wei Li
culture, the purity of isolated LCs was >90% as revealed by 3β-HSD staining ( Zhao et al. 2008 ). To study whether MTA3 expression was regulated by moderate oxidative stress, primary LCs or TM3 cells were challenged with different doses of H 2 O 2 or
Jacinta H Martin, Brett Nixon, Shenae L Cafe, R John Aitken, Elizabeth G Bromfield, and Tessa Lord
binding (sperm-egg fusion protein Juno (JUNO), astacin-like metalloendopeptidase (ASTL; also known as ovastacin)). Importantly, this updated review of the literature continues to demonstrate the intricate association between oxidative stress, mitochondrial
Tania Morielli and Cristian O'Flaherty
al . 1997 , Hasegawa et al . 1997 , Anderson & Williamson 1988 , Smith et al . 2006 ). Interestingly, all the above-mentioned conditions have the oxidative stress as an important component of their pathophysiological mechanisms ( Brennemann et
R John Aitken
Introduction Redox reactions are an essential component of living systems and exist in a state of dynamic equilibrium whereby the loss (oxidation) and gain (reduction) of electrons are carefully balanced. Oxidative stress is created when the