Search Results

Brown Norway rats. This suggests that in this strain, as in men, there is primary hypogonadism, with age-related changes in Leydig cell steroidogenesis occurring at the gonadal level rather than secondary to hypothalamic–pituitary changes. TS

Introduction The ovarian follicle is composed of an oocyte; it includes granulosa cells (GC) that border the antrum and is filled with follicular fluid. GC have two essential functions: cell proliferation and steroidogenesis. Due to their

. 2014 ). Interestingly, studies in non-mammalian vertebrates have been devoted to clarify Kp role in both spermatogenesis and steroidogenesis ( Tena-Sempere et al. 2012 ). In the prepubertal teleost Scomber japonicus, peripheral injection of Kp-15

Introduction Ovarian folliculogenesis and steroidogenesis are primarily regulated by hormonal secretions of hypothalamo–hypophysial–ovarian axis. Nevertheless, studies on mammals in recent decade provide evidence that some cytokines, growth

several miRNA (miR-29a, -29c, -142, -451 and -335) expression ( Liu et al. 2014 ). In this study, we showed that steroidogenesis and STAR expression were negatively regulated by miR-150 in primary Leydig cells. In detail, miR-150 can bind directly to

. 2016 ). Physiologically, verified by immunohistochemistry, BMAL1 expression significantly increased during corpus luteum formation ( Wiggins & Legge 2016 ). Female mice with Bmal1 knockout were inspected with impaired steroidogenesis, corpus luteum

physiological processes in the ovary including somatic cell proliferation, cyto-differentiation and apoptosis, oocyte maturation, steroidogenesis and angiogenesis. Angiogenesis plays an indispensible role in follicle and CL development and is a highly

steroidogenesis ( Ehrmann et al. 1997 , Vrbikova et al. 2001 , Bertoldo et al. 2014 ). Previous studies have shown that treatment with metformin decreased the abundance of proteins related to steroidogenesis and decreased secretion of progesterone and

mitochondrial oxidant signaling to NRF1 ( Okoh et al. 2015 ), knockdown of NRF1 blocks E 2 stimulation of mitochondrial biogenesis and activity ( Mattingly et al. 2008 ). These studies indicate NRF1 may be involved in the regulation of steroidogenesis

 μM) have been recorded ( Sjoberg et al . 1985 ). Previous in vitro studies of phthalate exposure have focused on the effects on human chorionic gonadotropin (hCG)- or 8-Br-cAMP-induced steroidogenesis. Alterations in basal steroid synthesis may be