THE INVASIVENESS OF TRANSPLANTED MOUSE TROPHOBLAST AND THE INFLUENCE OF IMMUNOLOGICAL FACTORS

in Reproduction

Summary.

Experiments are described which assess the relative developmental capacities of morulae, blastocysts and ectoplacental cones transplanted to the mouse testis. The pre-implantation stages developed less successfully, yet frequently gave rise to embryonic or extra-embryonic elements as well as trophoblast. The ectoplacental cones almost invariably developed and produced a luxuriant growth of trophoblast; this trophoblast caused a measurable increase in the weight of the testis which was shown histologically to be a direct indication of the degree of trophoblast invasion into the testis tissue. Ectoplacental cones were transplanted within and between inbred strains of mice. Those transplanted to genetically dissimilar hosts produced a greater increase in testis weight; thus trophoblast invasion appears to be more extensive when there is antigenic difference between the trophoblast and the host. These findings are discussed with reference to immunological factors in placentation.

If the inline PDF is not rendering correctly, you can download the PDF file here.

 

     An official journal of

    Society for Reproduction and Fertility

 

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 69 16 0
PDF Downloads 76 9 0