Urinary gonadotrophins have frequently been measured during the menstrual cycle (see Evans & Simpson, 1950; Loraine & Schmidt-Elmendorff, 1963). The most commonly applied method of assay has been that depending on the uterine response in immature mice, which measures both follicle-stimulating hormone (fsh) and luteinizing hormone (lh) (Brown & Billewicz, 1962), and this might explain why some workers have found that it fails to provide evidence of a meaningful relationship between pituitary and ovarian function (Loraine & Schmidt-Elmendorff, 1963). Preliminary experiments (Brown, Wells & Cunningham, 1964) have suggested that the method of Cunningham (1962) might be useful in demonstrating significant changes in pituitary gonadotrophic function if such occur. The method depends on the induction of ovulation in immature mice, and
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