Stimulation of in vitro ovulation and contraction of brook trout (Salvelinus fontinalis) follicles by adrenaline through α-adrenoreceptors

in Reproduction

The effects of adrenaline and adrenoreceptor antagonists on ovulation and follicle wall contraction were investigated in brook trout (Salvelinus fontinalis) follicles using in vitro incubation systems. Adrenaline significantly stimulated a dose-dependent increase in ovulation and follicle contraction at concentrations between 1.0 and 100 μmol l−1 The ovulatory and contractile effects of 10 μmol adrenaline l−1 could be blocked by the α1-adrenoreceptor antagonists WB-4101 and benoxathian, and by the α2-antagonist yohimbine. WB-4101 was the most potent blocker, significantly inhibiting ovulation and contraction at 1.0 μmol l−1. In contrast, the β-antagonist propranolol (100–0.001 μmol l−1) was totally ineffective in blocking adrenaline-induced ovulation and follicle contraction. The results indicate that there is a strong correlation between the effects of adrenaline on ovulation and contraction. In addition, the antagonist studies indicate that adrenaline stimulates ovulation and follicle contraction of brook trout follicles through α-adrenoreceptors.

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