Unilateral control of ovarian oxytocin release and the facilitatory effects of insulin-like growth factor-I in sheep
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Prostaglandin F2α (PGF2α)-induced release of ovarian oxytocin was investigated to determine whether the effect in vivo was local. [3H]PGF2α infused downstream into a single ovarian lymphatic was transferred into the adjacent ovarian vasculature (estimated transfer 1.1 and 1.7%, two experiments). When unlabelled PGF2α was infused in a similar manner (76 pmol min−1), there was a prompt eightfold increase in ovarian oxytocin release from the adjacent ovary containing a corpus luteum, but no effect on the opposite corpus luteum, showing that the effect was local. Instillation of 2% lignocaine into the ovarian vascular pedicle did not affect PGF2α-induced oxytocin release, supporting the idea that neural mechanisms are not involved. Repeated doses of PGF2α given close-arterially produced a successive reduction in oxytocin release. This effect was prevented by a prior infusion of insulin-like growth factor-I (IGF-I), which itself gave a small, but significant, increase in oxytocin release. The results show that PGF2α in ovarian lymphatics acts locally and directly to stimulate ovarian oxytocin secretion, that repeated exposure of the corpus luteum to pulses of PGF2α can result in tachyphylaxis, and that this latter effect can be ameliorated by IGF-I infused in vivo.
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