Plasma concentrations of FSH, LH, thyroid-stimulating hormone and growth hormone after exogenous stimulation with GnRH, TRH and GHRH in Booroola ewes that are homozygous carriers or non-carriers of the FecB gene
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The aim of the present study in Booroola ewes, either homozygous (BB) or non-carriers (++) of the FecB gene, was to test the specificity of the pituitary responses to exogenous hypothalamic releasing hormones by examining the plasma concentrations of FSH, LH, thyroid-stimulating hormone (TSH) and growth hormone (GH) after injecting the animals with different doses of GnRH, thyroid-releasing hormone (TRH) or growth-hormone-releasing hormone, (GHRH) which were administered on separate occasions. The animals (n = 8 per dose) received 0, 3.1 or 12.5 μg of thyroid-releasing hormone and GnRH (i.v.), whereas they (n = 9–13 per dose) received 0, 6.0 or 16.0 μg GHRH (i.v.). For each experiment there were no differences between the genotypes in bodymass or age. Gene-specific differences in the mean pretreatment concentrations of plasma FSH (BB > ++; P < 0.05) but not of LH, TSH or GH were noted. After treatment with GnRH, TRH or GHRH, significant effects of dose were noted for all the hormones; however, a gene-specific effect was observed only for FSH in response to GnRH (BB > ++; P < 0.01) with no genotype × dose interaction (anova). For LH, the effects of genotype and the genotype × dose interaction almost reached significance at the 5% level (genotype, P = 0.055; genotype × dose, P = 0.067). For TSH and GH the respective genotype × dose interactions were not significant. These results support the hypothesis that the FecB gene in Booroola ewes influences the release of pituitary hormones in response to hypothalamic releasing hormones only in the case of GnRH, which results mainly in different plasma concentrations of FSH.
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