Differences in blood flow to uterine segments and placentae in relation to sex, intrauterine location and side in pregnant rats
in ReproductionSearch for other papers by M. D. Even in
Current site
Google Scholar
PubMed
Search for other papers by M. H. Laughlin in
Current site
Google Scholar
PubMed
Search for other papers by G. F. Krause in
Current site
Google Scholar
PubMed
Search for other papers by F. S. vom Saal in
Current site
Google Scholar
PubMed
The effects of location within the left or right uterine horn, position within each uterine horn, and fetal sex on fetal bodymass, blood flow to individual uterine segments associated with fetuses, and blood flow to the maternal portion of the placenta were investigated in rats. Sprague–Dawley rats were anaesthetized on day 5, 10, 15, 20, 21 or 22 of pregnancy, and radioactive microspheres with diameters of 15 mm were injected via a left ventricular cannula to measure blood flow to tissues. Tissues were weighed wet, and the rate of blood flow, corrected for wet mass (ml min−1 g−1 tissue), was calculated. Microspheres were not detected in fetuses, suggesting that they did not pass from maternal into fetal blood. Uterine blood flow was greater at the cervical and ovarian ends than in the middle of the uterus; on day 15 the rate of blood flow at the cervical and ovarian ends of each uterine horn was over twice that in the middle. The blood flow to the right uterine horn was greater than to the left horn. Blood flow to placentae increased dramatically between day 15 and day 20. There were marked differences in architecture between the uterine artery feeding the ovarian end of the right and left uterine horn, and blood flow to placentae located at the ovarian end of the right uterine horn was greater than to placentae in the same location in the left uterine horn. The blood flow to placentae and fetal bodymass were greater for female than for male fetuses on day 20, but on day 22 the reverse was observed. There was no effect of the number of fetuses in the same uterine horn on blood flow to the uterus or placentae, or on fetal or placental mass.
Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 209 | 63 | 0 |
| PDF Downloads | 185 | 82 | 4 |
Online ISSN: 1741-7899
Print ISSN: 1470-1626
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519