Appearance and cellular distribution of lectin-like receptors for α1-acid glycoprotein in the developing rat testis

in Reproduction

A histochemical avidin–biotin technique with three different α1-acid glycoprotein glycoforms showed pronounced alterations in the cellular localization of two α1-acid glycoprotein lectin-like receptors during cell differentiation in the developing rat testis. The binding of α1-acid glycoprotein glycoforms to their receptors is inhibited by steroids. Testosterone, oestradiol and progesterone inhibited the binding of α1-acid glycoprotein glycoform A to its receptor. Cortisone, aldosterone, oestradiol and progesterone inhibited the binding of α1-acid glycoprotein glycoforms B and C to their receptor. A difference in the cellular content of α1-acid glycoprotein glycoforms and α1-acid glycoprotein receptors separates the spermatocytes and the early spermatids from the late spermatids. The difference in receptor composition implies a difference in the effect of different steroid hormones. The Leydig cells contained α1-acid glycoprotein and lectin-like receptors for one of the glycoforms of α1-acid glycoprotein from birth. The interaction between α1-acid glycoprotein glycoforms and their receptors may modulate the actions of testosterone and other steroids in the testis.


An official journal of

Society for Reproduction and Fertility



Google Scholar

Related Articles



All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 18 18 6
PDF Downloads 38 38 9