The oxytocic activity of unextracted blood plasma of calving cows increased from undetectable levels (<1 × 10 -10 i.u./ml) up to approximately 1 × 10 -4 i.u./ml within a few minutes before the time of expulsion of the calf, followed by a rapid decrease after parturition. The results indicate that the initiation of calving is not dependent on the oxytocic activity in the blood, but that blood oxytocic activity plays a role in the expulsion of the calf. These findings support the view that oxytocin has a physiological role in labour.
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