THE EFFECTS OF RESERPINE ON OVULATION AND ON THE CORPUS LUTEUM OF THE GUINEA-PIG
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Summary.
Sixty adult female guinea-pigs were treated with reserpine for a study of its effects on the ovaries and reproductive cycle. In the guinea-pig, as in the rat, it will inhibit ovulation, but whereas reserpine, acting through the hypothalamus and pituitary, is luteotrophic and lactogenic in the rat, in the guinea-pig it is neither, but has an inhibitory action on the development and function of the corpus luteum.
Reserpine does not interfere with ovo-implantation in the guinea-pig but later, at 14 to 15 days pregnant when an embryo is more vulnerable and requires a greater supply of progesterone, reserpine causes abortion.
After reserpine treatment, most follicles were unable to respond by ovulation to purified sheep luteinizing hormone, which will induce ovulation in the normal guinea-pig.
Apart from considerations of dosage, species differences in the reactions of the ovaries to reserpine are probably connected with differences in the hypothalamic-hypophysial neuro-secretory paths.
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