THE EFFECT OF U-11634 ON THE VAGINAL CYTOLOGY OF RATS
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5-(α,α,α-Trifluoro-m-tolyloxymethyl)-2-oxazolidinethione, referred to as U-11634 (Youngdale, Duncan, Emmert & Lednicer, 1966), inhibits pregnancy in rats when administered at doses of 2·5 mg or above for the first 7 days of pregnancy or at a single dose of 5·0 mg or above when administered on the 4th day of pregnancy. In classical hormone assays, U-11634 was devoid of uterotrophic, anti-oestrogenic (in immature ovariectomized rats), progestational (McPhail assay), androgenic (in immature castrate rats), and gonadotrophininhibiting (in immature intact male rats) activities at therapeutic doses or reasonable multiples thereof (Duncan, Johnston & Lyster, 1965). It did not inhibit endometrial proliferation (McPhail assay, three rabbits/dose) when administered subcutaneously at doses of 0·0, 2·5, 25 and 50 mg/kg concomitant with 0·20 mg of progesterone injected at a separate site.
To assess further the effect of U-11634 on the pituitary-gondal axis,
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