THE EFFECT OF AN ORAL CONTRACEPTIVE ON URINARY GONADOTROPHIN IN WOMEN AT MID-CYCLE
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In a previous study of the effect of an oral contraceptive (Brown, Wells & Cunningham, 1964), urinary gonadotrophin was measured by its ability to induce ovulation in mice (Cunningham, 1962; Wells, Khosla & Brown, 1964). This method of assay, though not specific for luteinizing hormone, was considered appropriate for investigating the action of drugs which prevent ovulation. The study of two women, one through two complete menstrual cycles and the other through three, showed that treatment with a combination of norethynodrel and mestranol abolished the mid-cycle peak of gonadotrophin excretion. Before further study of the mode of action of oral contraceptives, more experience was gained with the pattern of excretion of gonadotrophin during the normal menstrual cycle measured with this assay
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