SOME ANTIFERTILITY EFFECTS OF NILEVAR (17α-ETHYL-19-NORTESTOSTERONE), A PROGESTATIONAL STEROID, IN THE FEMALE GUINEA-PIG
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Summary.
In the adult guinea-pig the progestational steroid Nilevar (17α-ethyl-19-nortestosterone) alters the pattern of the oestrous cycle, inhibiting opening of the vagina. Ovulation is prevented—as judged by the absence of corpora lutea in the ovaries—but follicles reach a stage of maturity. Gonadotrophins are present in the pituitary gland of the Nilevar-treated guinea-pigs in amounts comparable with those of their oil-treated controls, as shown by tests for total gonadotrophins and for follicular stimulating hormone alone.
It is suggested that in the adult guinea-pig Nilevar does not exert its effect directly on the growing follicle but prevents the action of gonadotrophins on the mature follicle. The results indicate an inhibition of the sudden release of gonadotrophins which probably precedes ovulation. This effect may be at the hypothalamic level of the brain where an inhibition of the gonadotrophin-releasing factors could occur, but the results do not preclude an inhibition at the ovarian level.
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