Tumour suppressor genes in sporadic epithelial ovarian cancer

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Authors:
Y Liu
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TS Ganesan
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DOI:
https://doi.org/10.1530/rep.0.1230341
Volume/Issue:
Volume 123: Issue 3
Page Range:
341–353
Article Type:
Research Article
Online Publication Date:
01 Mar 2002
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Ovarian cancer is the most frequent cause of death from gynaecological malignancies in the western world, and sporadic epithelial ovarian cancer is its most predominant form. The aetiology of sporadic ovarian cancer remains unknown. Genetic studies have enabled a better understanding of the evolution of tumour progression. A major focus of research has been to identify tumour suppressor genes implicated in sporadic ovarian cancer over the past decade. Several tumour suppressor genes have been identified by strategies such as positional cloning and differential expression display. Further research is warranted to understand fully their contribution to the pathogenesis of sporadic ovarian cancer.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899