Various attempts have been made to utilize the absorptive properties of the vagina for administration of therapeutic drugs. The vaginal absorption of organic elements, their subsequent isolation in urine, serum or manifestation of their endocrine effects, has been demonstrated with phenylmercuric acetate in the human (Eastman & Scott, 1944) and rat (Laug & Kunze, 1949), and with insulin in the dog (Fischer, 1923) but not the human (Woodyatt, 1922). Penicillin is absorbed within 60 min by the human vagina (Lovelady, Randall & Hosfeld, 1946; Goldberger, Walter & Lapid, 1947), while vaginal absorption of sulphanilamides exhibits daily variation (Carrington, Rohrer, Jones & Moore, 1944).
While investigating oestrogen metabolism, the uptake of tritiated oestrogens by spayed mouse genital tissues after intravenous (Stone, Baggett & Donnelly, 1963), subcutaneous (Stone, 1963) or
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