Measurements of histamine in control and IUCD-containing uterine horns of the rat in di-oestrus and L4 of pregnancy showed that device-containing horns had a higher concentration and content per horn than did control horns at both times. In control horns, the histamine content on L4 was about one-half of the value observed in di-oestrus, while in IUCD-containing horns the histamine content on L4 was the same as the di-oestrous value. These data are interpreted in terms of a chronic inflammatory response in the IUCD-containing horn.
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