Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-τ secretion, and gene expression

in Reproduction
Authors:
Barbara Loureiro Department of Animal Sciences and D.H. Barron Reproductive and Perinatal Biology Research Program, Ovatech LLC, University of Florida, PO Box 110910, Gainesville, Florida 32611-0910, USA

Search for other papers by Barbara Loureiro in
Current site
Google Scholar
PubMed
Close
,
Jeremy Block Department of Animal Sciences and D.H. Barron Reproductive and Perinatal Biology Research Program, Ovatech LLC, University of Florida, PO Box 110910, Gainesville, Florida 32611-0910, USA
Department of Animal Sciences and D.H. Barron Reproductive and Perinatal Biology Research Program, Ovatech LLC, University of Florida, PO Box 110910, Gainesville, Florida 32611-0910, USA

Search for other papers by Jeremy Block in
Current site
Google Scholar
PubMed
Close
,
Mauricio G Favoreto Department of Animal Sciences and D.H. Barron Reproductive and Perinatal Biology Research Program, Ovatech LLC, University of Florida, PO Box 110910, Gainesville, Florida 32611-0910, USA

Search for other papers by Mauricio G Favoreto in
Current site
Google Scholar
PubMed
Close
,
Silvia Carambula Department of Animal Sciences and D.H. Barron Reproductive and Perinatal Biology Research Program, Ovatech LLC, University of Florida, PO Box 110910, Gainesville, Florida 32611-0910, USA

Search for other papers by Silvia Carambula in
Current site
Google Scholar
PubMed
Close
,
Kathleen A Pennington Department of Animal Sciences and D.H. Barron Reproductive and Perinatal Biology Research Program, Ovatech LLC, University of Florida, PO Box 110910, Gainesville, Florida 32611-0910, USA

Search for other papers by Kathleen A Pennington in
Current site
Google Scholar
PubMed
Close
,
Alan D Ealy Department of Animal Sciences and D.H. Barron Reproductive and Perinatal Biology Research Program, Ovatech LLC, University of Florida, PO Box 110910, Gainesville, Florida 32611-0910, USA

Search for other papers by Alan D Ealy in
Current site
Google Scholar
PubMed
Close
, and
Peter J Hansen Department of Animal Sciences and D.H. Barron Reproductive and Perinatal Biology Research Program, Ovatech LLC, University of Florida, PO Box 110910, Gainesville, Florida 32611-0910, USA

Search for other papers by Peter J Hansen in
Current site
Google Scholar
PubMed
Close

Free access

Sign up for journal news

The authors apologise for an error in the results reported in this article published in Reproduction (vol 141, pp 617–624). A mathematical error resulted in calculation of values for IFN in uterine flushings that were too high. The corrected results are presented in Figure 1 (published in full below with the corrected figure legend).

Figure 1
Figure 1

Individual values of antiviral activity in uterine flushings (top) in pregnant cows and length of recovered conceptuses (bottom). Triangles represent tubular conceptuses and circles represent filamentous conceptuses. In the bottom panel, conceptuses that were not recovered intact are represented by closed circles. The horizontal bars represent the mean value for each treatment. Antiviral activity was not affected by treatment. However, when considering only those cows in which detectable antiviral activity was present, antiviral activity was greater for cows receiving CSF2-treated conceptuses (P<0.05). Conceptus length was not significantly affected by treatment.

Citation: REPRODUCTION 147, 2; 10.1530/REP-10-0511e

Note that the correlation between conceptus length and IFN concentration in uterine flushings was 0.08 and not 0.02 as stated in the paper. The range of IFN concentrations in uterine flushings ranged from non-detectable to almost 70 000 IU/mL (and not the 9 000 000 U/ml as stated in the paper). In addition, the concentration of IFN in uterine flushings of the nonpregnantcow with detectable IFN was 494 IU/ml rather than 59 049 IU/mL. For all cows, there was a non-significant trend for antiviral activity to be greater for cows receiving CSF2-treated conceptuses than for cows receiving control conceptuses. This difference was P<0.05 (rather than the P=0.07 as stated in the paper) when only cows with detectable antiviral activity were considered.

The authors regret this error.

 

  • Collapse
  • Expand
  • Individual values of antiviral activity in uterine flushings (top) in pregnant cows and length of recovered conceptuses (bottom). Triangles represent tubular conceptuses and circles represent filamentous conceptuses. In the bottom panel, conceptuses that were not recovered intact are represented by closed circles. The horizontal bars represent the mean value for each treatment. Antiviral activity was not affected by treatment. However, when considering only those cows in which detectable antiviral activity was present, antiviral activity was greater for cows receiving CSF2-treated conceptuses (P<0.05). Conceptus length was not significantly affected by treatment.