FAILURE OF 109Cd TO TRAVERSE SPERMATOGENIC PATHWAY

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Authors:
SAMUEL A. GUNN
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THELMA CLARK GOULD
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, and
W. A. D. ANDERSON
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DOI:
https://doi.org/10.1530/jrf.0.0160125
Volume/Issue:
Volume 16: Issue 1
Page Range:
125–128
Article Type:
Research Article
Online Publication Date:
Jun 1968
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Wetterdal (1958) showed that zinc, an element essential for spermatogenesis, is incorporated into developing spermatogenic elements within the testis. Cadmium, physico-chemically similar to zinc, causes selective destruction of the testis; administration of zinc prevents cadmium damage (Parizek, 1957; Kar, Das & Mukerji, 1960; Gunn, Gould & Anderson, 1961). Parizek (1960) suggested that cadmium exerts testicular injury by displacing zinc from its natural sites in seminiferous tubules and that the haemorrhagic reactions, so characteristic of cadmium injury, are a secondary effect. More recent evidence indicates that the vascular endothelium of the testis is the primary site of damage and that necrosis of parenchyma follows secondarily (Gunn, Gould & Anderson, 1963a; Chiquoine, 1964; Mason, Brown, Young & Nesbit, 1964; Niemi & Kormano, 1965; Waites & Setchell, 1966). The following experiments were initiated using radio-isotopes to determine

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Print ISSN:
1470-1626
Online ISSN:
1741-7899