In the mouse at implantation, the uterus responds to the presence of a blastocyst by producing a massive cellular reaction in the stroma to form a deciduoma. The period during which the decidual cell reaction may be initiated is fairly well defined, and the reaction depends on adequate sensitization of the uterus by the ovarian hormones. In this study, two non-traumatic methods of deciduoma induction were employed, intra-luminal injection of arachis oil (Finn & Hinchliffe, 1965), and intra-luminal injection of air, which was reported by Orsini (1963) to be an effective stimulus in the hamster and the rat.
Virgin mice of the random outbred Q strain, weighing 20–25 g, and pseudopregnant after mating with vasectomized males, were used. The day on which the vaginal plug was found was taken as the 1st day of pseudopregnancy.
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