The new totally synthetic progestational steroid norgestrel has been subjected to a clinical trial in gynaecological and endocrine cases and for oral contraception, and its toxicity and side-effects have been investigated. The effect of norgestrel alone and in combination with ethinyl oestradiol in various dosage/time schedules on the endometrium has been studied. The previous reports of its effectiveness in low dosage combinations with oestrogen with absence of significant side-effects or toxicity have been confirmed. These findings, together with its very high potency, make it an important addition to progestational therapy in gynaecological practice and for oral contraception.
If the inline PDF is not rendering correctly, you can download the PDF file here.