Foreign bodies in the uteri of germ-free and conventional rats caused a weight increase only in those portions of the uterus where there was an inflammatory reaction. In oestrogen-deprived, conventional animals, uterine inflammation prevented involution and the disappearance of nucleoli from the endometrium. It appears that inflammation is responsible for the weight increase in uteri containing foreign bodies. It is suggested that inflammation may also be responsible for the luteolytic effect of uterine foreign bodies.
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