EFFECT OF AN IUCD ON AN ENDOMETRIAL RESPONSE TO STEROID HORMONES IN THE RAT

in Reproduction
Author:
K. BROWN-GRANT
Search for other papers by K. BROWN-GRANT in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1530/jrf.0.0180475
Volume/Issue:
Volume 18: Issue 3
Page Range:
475–480
Article Type:
Research Article
Online Publication Date:
Apr 1969
Free access

Sign up for journal news

Summary.

The presence of a silk thread in the lumen of the upper half of one horn of the uterus of the rat renders that horn sterile. The raised uterus-plasma concentration for radio-iodide that normally occurs on Day 3 of pregnancy is abolished by such a thread placed unilaterally; the control horn shows a normal response. The increase in the uterus-plasma ratio for 131I produced by the administration of progesterone to ovariectomized rats is significantly reduced, but not abolished, in a uterine horn carrying a thread. The inhibition by oestrogen of this response to progesterone is enhanced by the presence of a thread. Changes in the radio-iodide concentration ratio may provide a convenient model system for studies on the mechanism of action of an IUCD in the rat.

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 121 45 4
PDF Downloads 42 10 3

 

  • Collapse
  • Expand
Print ISSN:
1470-1626
Online ISSN:
1741-7899