Despite the probable existence of a protective layer around trophoblastic cells (Bradbury, Billington & Kirby, 1965; Currie & Bagshawe, 1968), there is evidence suggesting that antigenic diversity between mother and foetus has immunological consequences (Billington, 1964; McLaren, 1965; James, 1965). Billington (1965) reported that trophoblast transplanted to the testis of mice genetically dissimilar from the donor was more invasive than trophoblast transplanted to genetically similar mice. The present work was designed to investigate such an effect of genetic difference and, in particular, to see whether it was due: (1) to a response by the testis to a foreign trophoblast, (2) to a response by the trophoblast to a foreign testis, or (3) to a combination of both. In order to distinguish between these possibilities, transplants were carried out in various combinations between two strains of mice and their
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