IMPLANTATION AND DEVELOPMENT OF MOUSE EGGS TRANSFERRED TO THE UTERI OF NON-PROGESTATIONAL MICE

in Reproduction
Author:
THOMAS P. COWELL
Search for other papers by THOMAS P. COWELL in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1530/jrf.0.0190239
Volume/Issue:
Volume 19: Issue 2
Page Range:
239–245
Article Type:
Research Article
Online Publication Date:
Jul 1969
Free access

Sign up for journal news

Summary.

Four-day-old mouse embryos were transferred to the uterine lumen of virgin cyclic and ovariectomized mice; the eggs 'implanted' and developed only in mice whose endometrium was previously traumatized with a glass scraper. The histology of the mechanically induced implantation sites is described and similarities to normal implantation sites are discussed.

Implanted embryos developed only to stages equivalent to 5 to 9 days of normal pregnancy, but the trophoblast continued to proliferate and invaded the endometrium, eroding maternal blood vessels and distending the uterus. In five of eight ovariectomized mice, plaques of decidual-like cells were found near the trophoblast 7 to 12 days after transfer.

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 397 254 52
PDF Downloads 168 56 7

 

  • Collapse
  • Expand
Print ISSN:
1470-1626
Online ISSN:
1741-7899