TRANSFER OF ZONA-FREE MOUSE EGGS TO UTERINE FOSTER MOTHERS
in ReproductionSearch for other papers by ANNE McLAREN in
Current site
Google Scholar
PubMed
Summary.
When blastocysts from pregnant mice 3½ days p.c. were transferred to the uteri of synchronous pseudopregnant recipients, the time of onset of implantation (judged by the appearance of pontamine blue reactivity in the uterus) was not altered by removal of the zona pellucida. The competence of zona-free blastocysts to elicit the pontamine blue reaction was similar to that of control blastocysts. The low implantation rate of eight-cell embryos from donors 2½ days p.c., transferred to recipients 3½ days p.c., was not increased by previous removal of the zona. It was concluded that, in mice, the decidualizing stimulus from the blastocyst to the uterus stems neither from the zona itself, nor from cellular contact between the vitelline surface and the uterine epithelium.
Removal of the zona by treatment with pronase reduced the viability of transferred blastocysts, so that by mid-gestation the proportion of zona-free blastocysts represented by live embryos was significantly below the control level.
Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 153 | 41 | 6 |
| PDF Downloads | 102 | 30 | 4 |
Online ISSN: 1741-7899
Print ISSN: 1470-1626
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519