PATHOGENESIS OF EARLY EMBRYONIC MORTALITY CAUSED BY FASTING PREGNANT RATS AND MICE FOR SHORT PERIODS

in Reproduction

Summary.

Daily treatment with progesterone and chorionic gonadotrophin was found to protect pregnancy in fasted mice so that it lasted at least 6 days longer than in control mice fasted from the end of the 3rd to 5th days after mating. Pregnancy could not, however, be maintained beyond the 14th or 15th day by these means. The pathogenesis of the embryonic mortality caused by fasting, therefore, appears to involve a failure of hypophyseal gonadotrophic function. Adrenalectomy and implantation with desoxycorticosterone acetate did not protect pregnancy in fasted rats, suggesting that the mortality was not caused by hypersecretion of corticosterone.

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