THE FOURTH OLIVER BIRD LECTURE APPROACHES TO THE CONTROL OF FERTILITY BASED ON IMMUNOLOGICAL PHENOMENA

in Reproduction
ContentsIntroductionIllustrative experiments on fertilization and development in invertebratesIII. Immunological antifertility effects in mammalsIn vitro treatment of spermatozoaPossible selective action of antibodies with respect to sex and other genetic characteristicsAspermatogenesisAdjuvant-immunization of females with seminal materialsSperm-agglutinins in sterile menImmunization with placental and foetal materialsAntihormonesNaturally occurring antigen-antibody-like systemsThe blood groupsNatural heteroagglutininsAntagglutinsFertilizins and antifertilizinsUnion of spermatozoon and egg in terms of interaction of receptor substances and pinocytosisReferencesI. INTRODUCTIONThe investigation of immunological methods of controlling fertility is far from new. Immunological experiments with materials from the reproductive systems of animals date back at least to the end of the last century when Metchnikoff (1899, 1900) injected guinea-pigs with the semen or with the macerated testes of human beings, bulls, guinea-pigs and rabbits. In these original experiments, Metchnikoff found that the serum of the guinea-pig agglutinated and

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