The administration of chlormadinone acetate to pubescent lambs suppressed the growth of the reproductive tract as a whole, reduced both ejaculate volume and fructose concentration and delayed the appearance of spermatozoa. Following a period of suppression, a `rebound' effect was seen with fructose levels exceeding those of the controls for a short period and then returning to normal.
Sperm production and motility were reduced and the number of dead and abnormal spermatozoa increased.
Treatment was least effective after the onset of spermatogenesis and the inhibitory effect was counteracted by injection of pituitary gonado-trophin (icsh). There was no effect on growth rate.
Intravenous injection of methallibure appeared to have no effect on testicular growth, and did not delay the first appearance of spermatozoa, but fructose secretion by the seminal vesicles was increased. There was an increase in the number of spermatozoa produced and also in the numbers of dead and abnormal forms. Methallibure did not affect the growth rate.
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