DISSOCIATION OF UTEROTROPHIC ACTION FROM IMPLANTATION-INDUCING ACTIVITY IN TWO NON-STEROIDAL OESTROGENS (COUMESTROL AND GENISTEIN)

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Authors:
E. PEREL
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and
H. R. LINDNER
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DOI:
https://doi.org/10.1530/jrf.0.0210171
Volume/Issue:
Volume 21: Issue 1
Page Range:
171–175
Article Type:
Research Article
Online Publication Date:
Feb 1970
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Summary.

The phyto-oestrogens coumestrol (7,12-dihydroxycoumestan) and genistein (5,7,4′-trihydroxyisoflavone) induced uterine growth in ovariectomized rats, but failed to induce ovum implantation in mated ovariectomized, gestagen-maintained rats and in intact lactating rats when given at dose levels effective in uterine weight assays. Oestradiol17β, under similar conditions, induced ovum implantation even at dose levels below those required for a uterine weight response. Diethylstilboestrol and large doses of oestradiol-17α (5 to 10 μg) were effective in both assays. It is suggested that different uterine receptors may be involved in mediating the uterine-growth-promoting and implantationinducing actions of oestrogen.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899