AY-11483, A NEW TYPE OF ORALLY ACTIVE OESTROGEN

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Authors:
C. REVESZ
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,
U. K. BANIK
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, and
Y. LEFEBVRE
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DOI:
https://doi.org/10.1530/jrf.0.0220027
Volume/Issue:
Volume 22: Issue 1
Page Range:
27–32
Article Type:
Research Article
Online Publication Date:
Jun 1970
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Summary.

The oral oestrogenic activity of AY-11483 has been compared to that of oestriol and mestranol. The compound shows significant activity in the vaginal cornification test in rats and mice; however, it has a relatively weak effect in the uterotrophic assay in rats, mice and rabbits. Furthermore, like oestriol, it exerts a weak effect on the endometrium in rabbits. Based on our findings, AY-11483 should be classified as an impeded oestrogen with possible clinical application.

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PDF Downloads 88 26 2

 

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Print ISSN:
1470-1626
Online ISSN:
1741-7899