AY-11483, A NEW TYPE OF ORALLY ACTIVE OESTROGEN

in Reproduction
Authors:
C. REVESZ
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U. K. BANIK
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Y. LEFEBVRE
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Summary.

The oral oestrogenic activity of AY-11483 has been compared to that of oestriol and mestranol. The compound shows significant activity in the vaginal cornification test in rats and mice; however, it has a relatively weak effect in the uterotrophic assay in rats, mice and rabbits. Furthermore, like oestriol, it exerts a weak effect on the endometrium in rabbits. Based on our findings, AY-11483 should be classified as an impeded oestrogen with possible clinical application.

 

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