The secretion of fluid in the Fallopian tube is greatest about oestrus and diminishes during the luteal phase of the cycle (e.g. Perkins, Goode, Wilder & Henson, 1965). Cannulation of both ends of the Fallopian tube in the ewe and volumetric collection of the secretion has shown that most of the fluid flowed through the ampullar orifice, but that there was marked increase in flow of fluid through the tubo-uterine junction about 4 days after the onset of oestrus (Bellve & McDonald, 1968). With the ovariectomized ewe injected with oestrogen, the peak flow through the tubo-uterine junction preceded that through the ampullar end (McDonald & Bellve, 1969). The mechanism which prevents a similar premature surge in isthmic flow in the intact ewe during the pre-ovulatory period, when oestrogen is in dominance (Moore, Barrett, Brown, Schindler,
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