COMPARATIVE EFFECTS OF METHYLENE, ETHYLENE AND PROPYLENE DIMETHANESULPHONATES ON THE MALE RAT REPRODUCTIVE SYSTEM

in Reproduction

Summary.

Histological changes in the rat testis were correlated with the antifertility effects of injections of three diol diesters of methanesulphonic acid. The compounds are consecutive members of a homologous series each differing by -CH2- from its neighbours. The diester of ethylene glycol (EDS) caused antispermatogenic effects resembling those following hypophysectomy and was associated with involution of prostate and epididymis; spermatocoele formation occurred in the latter organ. Methylene dimethanesulphonate and 1,3-propylene dimethanesulphonate induced changes consistent with spermatogonial damage resembling those produced by Myleran (busulphan).

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     An official journal of

    Society for Reproduction and Fertility

 

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