Oral contraceptives containing oestrogen and progestagen in high dosage may produce many undesirable side effects. The risk of thrombo-phlebotic episodes (Vessey & Doll, 1969) has caused much concern, but the possible long-term effects of the numerous metabolic changes have also to be considered. Amongst the latter, impaired glucose tolerance (Wynn & Doar, 1969) and increased levels of serum glutamic—pyruvate transaminase (SGPT) have been reported (Larsson-Cohn, 1965).
The use of norgestrel alone, given continuously in low dosage of 50 μg, is slightly less effective as a contraceptive than conventional combinations of oestrogen and progestagen (Foss, Svendsen, Fotherby & Richards, 1968) and 22% of cycles are shorter than 23 days in the women on this regimen, but the incidence of side effects is much lower (Foss, 1968). With the elimination of the
Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
|Sept 2018 onwards||Past Year||Past 30 Days|
|Full Text Views||62||62||4|
An official journal of