ANTIGENICITY, TOXICITY AND CROSS-REACTIONS OF MALE BAT (MYOTIS LUCIFUGUS) REPRODUCTIVE ORGANS

in Reproduction

Summary.

The antigenicity of male bat reproductive organs was studied using agar-gel diffusion. Four precipitin lines formed with testis and anti-testis, six lines with epididymis and anti-epididymis, and six lines with ampulla and anti-ampulla sera. Tissue extracts of liver, spleen, heart and uterus cross-reacted with the three antisera to produce three lines. Ampulla, epididymis and testis possessed at least one, three and one organ-specific antigens, respectively.

Nine proteins were detected in the seminal vesicles by agar-gel electrophoresis. One of these possessed potent toxic properties when injected into rabbits and mice. The toxic protein was isolated by zonal electrophoresis and by chromatography on Sephadex G-200. It migrated electrophoretically as a pre-albumin, had a molecular weight of approximately 44,600 and an LD50 value of 162μg/kg. The relationship between this protein and the unique phenomenon of bat sperm survival is unknown.

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     An official journal of

    Society for Reproduction and Fertility

 

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