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EFFECT OF MERCURIC COMPOUNDS ON THE MATERNAL TRANSMISSION OF SELENIUM IN THE PREGNANT AND LACTATING RAT

in Reproduction
Authors: J. PAŘÍZEK, I. OŠŤDALOVÁ, J. KALOUSKOVÁ, A. BABICKÝ, L. PAVLÍK and B. BÍBR
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DOI:
https://doi.org/10.1530/jrf.0.0250157
Page(s):
157–170
Volume/Issue:
Volume 25: Issue 2
Article Type:
Research Article
Online Publication Date:
May 1971
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Summary.

The administration of small amounts of mercuric compounds to pregnant rats, injected with 75Se in the form of selenite, markedly increased their retention of 75Se and simultaneously decreased the 75Se content in their foetuses. The 75Se concentration in the blood and liver of foetuses from these rats was much lower than in the blood and liver of foetuses from control mothers injected with [75Se]selenite only (or receiving zinc chloride instead of mercuric chloride). Retention of 75Se in the maternal organs and the passage of 75Se into the foetuses was partially dependent on the dose of mercury. In the doses used in these experiments, administration of mercuric salts did not result in foetal death nor in any significant effect on the weight of the offspring. In lactating rats, the administration of mercuric salts had a similar effect on the passage of 75Se into the milk. This resulted in a much smaller 75Se content in the newborn and suckling young of mothers exposed to small amounts of mercuric compounds during pregnancy or lactation than in control animals.

 

Print ISSN:
1470-1626
Online ISSN:
1741-7899

An official journal of

Society for Reproduction and Fertility

Volume 25: Issue 2

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Page(s):
157–170
Article Type:
Research Article
Print Publication Date:
01 Jan 1971
Online Publication Date:
May 1971

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PubMed

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 Society for Reproduction and Fertility