The effects of a potent antioestrogen—ICI 46,474—on cl were examined in pregnant and pseudopregnant rabbits and pregnant rats. In the rabbit, the antioestrogen interfered with the growth of cl, reducing significantly both the number and weight of the glands. In the pregnant rat, the weight of the cl was reduced and this was associated with a marked stimulation of mammary glands. These experiments provide further evidence that cl in the rabbit, and perhaps in the rat, require oestrogen for their functional maintenance.
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