ENDOCRINOLOGICAL STUDIES IN PATIENTS WITH KLINEFELTER'S SYNDROME TREATED WITH CLOMIPHENE
in ReproductionSummary.
The effect of clomiphene citrate on excretion values for fsh, lh, testosterone and epitestosterone has been investigated in four patients with Klinefelter's syndrome.
During the pretreatment period, levels of fsh and lh were above the normal range for male subjects, while readings of testosterone and epitestosterone were generally low.
Clomiphene produced a significant increase in fsh output in one subject and in lh excretion in another. In the remaining patients, pituitary gonadotrophic function was not affected by the administration of the compound. The effect of clomiphene on excretion values for C-19 steroids was inconsistent.
The study did not provide definite evidence regarding the site of of action of clomiphene in patients with Klinefelter's syndrome.
Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 66 | 57 | 0 |
| PDF Downloads | 30 | 28 | 3 |
Online ISSN: 1741-7899
Print ISSN: 1470-1626
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519