In the rhesus monkey, Macaca mulatta, mechanical traumatization of the endometrium at the sensitive stage of the menstrual cycle, or under the appropriate hormonal conditions, induces a superficial deciduomal reaction which is similar to the epithelial plaque formed during implantation (Hisaw, 1935; Hisaw, Greep & Fevold, 1937; Wislocki & Streeter, 1938; Rossman, 1940). A deciduomal reaction can be induced in the same way when the uterus contains an IUD (Kelly, Marston & Eckstein, 1969) and this suggests that the endometrium's sensitivity and responsiveness to a traumatic stimulus is not affected by the presence of an IUD. Mechanical trauma injures all the endometrial tissues, but the naturally implanting blastocyst provides quite a different stimulus, which is likely to affect just the surface epithelium of the endometrium. We have, therefore, extended our previous study and induced a deciduomal
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